Famous Actors Who Appeared on Seinfeld Before They Became A-List Stars

Debra Messing

Image Source:: Robert Hanashiro-USA TODAY Sports

Episodes: “The Wait Out” (Season 7, Episode 21); “The Yada Yada” (Season 8, Episode 19)

Messing actually appeared on two episodes of the show. A physician on the show, Messing initially dated Jerry after breaking up with a former fling. On her second appearance, Messing yet again was involved with Jerry — though he broke it off with her after her loose lips divulged secrets Jerry preferred to keep private (such as the fact that he hates dentists).