LOST: The Mysteries Remain Nearly 10 Years Later

Keaton, Fox and Hamm

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You either loved or hated Dr. Jack Shephard. The main protagonist of the series, Jack was ultimately played by Matthew Fox. However, Fox’s involvement only came after Michael Keaton turned down the role — citing his disdain to commit for the duration of the show. In addition to Keaton, Mad Men star Jon Hamm also auditioned for the pivotal role.